The invention discloses high-performance polyurethane as well as a preparation method and application thereof. The preparation method comprises the following steps: taking polyether polyol and polyisocyanate as main raw materials; adding certain amounts of nanocellulose crystal and nano-hydroxyapatite; carrying out a chain extending reaction, gas production and crosslinking reaction under the actions of a foaming agent, a stabilizer and a catalyst, standing for a period of time, and then putting a mixture into a baking oven for drying to obtain the high-performance polyurethane with remarkably-improved strength. According to high-performance polyurethane disclosed by the invention, the application range of the nanocellulose crystal is widened; and moreover, physical properties of a traditional polyurethane material can be improved.