The invention relates to the field of composite materials, in particular to a leather-core composite composition, a leather-core composite material and application thereof in field of 3D (three-dimensional) printing. The leather-core composite composition comprises a leather layer component and a core layer component which are independently stored; the leather-layer component is prepared from polyester with low melting point and a first inorganic filler, and the melting point of the polyester with low melting point is 110 to 140 DEG C; the core layer component is prepared from polyolefin and asecond inorganic filler; in the leather layer component, the usage amount of the first inorganic filler is 10 to 40 parts by weight in comparison with 100 parts of polyester with low melting point; in the core layer component, the usage amount of the second inorganic filler is 40 to 70 parts by weight in comparison with 100 parts of polyolefin by weight. The leather-core composite composition and/or the leather-core composite material has the advantages that the bond force between layers of a printed product is enhanced, the printing speed is improved, the printed product with better mechanical property can be obtained, and various additional properties can be obtained.