The present invention provides a capacitance detection circuit, a capacitance detection method, a touch detection device and a terminal device, which can overcome the influence of self-capacitance onself-capacitance detection and improve the sensitivity of self-capacitance detection. The capacitance detecting circuit is configured to detect a capacitance of N capacitors to be measured, wherein Nis greater than or equal to 2 and comprises: at least N-1 first front end circuits for converting the capacitance signals of the capacitors to be tested into first voltage signals and seeking the differences of the first voltage signals, at least one second front-end circuit for converting the capacitance signals of the capacitors to be measured into a second voltage signal and summing the secondvoltage signals, and a processing circuit. The differential signal output by each first front-end circuit and the sum signal output by each second front-end circuit determine the capacitance value ofeach of the N to-be-tested capacitors.