The invention discloses a composition capable of preventing diaper rash. The composition is prepared by, by weight, 10-28 parts of sodium sucrose octasulfate, 5-10 parts of bisabolol, 20-40 parts of solvent, 1-5 parts of solubilizer, 50-100 parts of deionized water and 10-20 parts of traditional Chinese medicine extract, wherein the traditional Chinese medicine extract is prepared by, by weight, 3-9 parts of radix pueraiae, 3-9 parts of rhizoma coptidis, 3-9 parts of cortex phellodendri, 4-10 parts of radix glycyrrhizae, 6-10 parts of indigo naturalis, 10-20 parts of honeysuckle, 4-8 parts ofmyrrh, 4-10 parts of radix angelicae dahuricae, 5-9 parts of adenosma indianum, 1-5 parts of angelica sinensis and 6-10 parts of talcum. The invention further discloses application of the compositionin the preparation of paper diaper surface-layer non-woven fabric. The composition is added into conventional fiber spinning oil or used for the finishing of the non-woven fabric. The composition hasthe advantages that the composition can inhibit enzyme activity, control the irritation of excrement enzyme allergen to the skin and block allergic reaction, the added traditional Chinese medicine extract has effects of clearing heat and promoting diuresis, resisting bacteria and inflammation and dispelling wind and detoxifying, and the traditional Chinese medicine extract can also promote skin growth, moisten the skin to allow the skin to recover the original color and avoid scar formation.