The invention discloses a multifunctional full-automatic intelligent manicure machine. The machine includes a manicure machine body and a central processing unit of an inner cavity of the manicure machine body; the manicure machine body is provided with a finger placing groove, a finger clamping groove is formed in the upper end of the finger placing groove, and the manicure machine body includesa nail polishing mechanism, a cleaning mechanism, a glue coating mechanism and a spraying mechanism; the spraying mechanism comprises a spraying gun and a T-shaped mounting base arranged in a T-shapedgroove in the upper end of the finger clamping groove in a sliding mode, the spraying gun is fixedly mounted at the lower end of a T-shaped supporting base, and a sprayer nozzle of the spraying gun faces the lower surface of the finger placing groove. Through arrangement of the spraying mechanism, the glue coating mechanism, the nail polishing mechanism, the cleaning mechanism and an LED lamp baking mechanism, the integrity and abundance of the functions of the manicure machine can be well ensured; since the cleaning mechanism and the nail polishing mechanism share one driving motor, troublesand labor are saved, energy is saved, and the environment is protected; through arrangement of a series of adjustable structures in the cleaning mechanism, the cleaning mechanism can be adjusted conveniently during use and is wide in range.