The invention discloses a manual craniotomy drill for experiments. The manual craniotomy drill comprises a positioning base, a drill tube, an adjusting nut, a fixing needle, a screwing handle and a cam assembly. The drill tube comprises a drill tube part, a drilling distance adjusting part and a knob part. Drilling teeth are formed at the lower end of the drill tube part, the fixing needle comprises a conical drill bit and a needle rod, a cam connection plate is formed at the upper end of the needle rod, the cam connection plate is provided with a cam connection hole, and the cam assembly comprises a handle and a cam. During use, the conical drill bit enters a skull by a proper depth, at the moment, the knob part is rotated, the drill teeth move downwards while rotating along with the drill tube, when a protrusion of the outer wall of the adjusting nut abuts against the positioning base, the skull is just drilled open, the conical drill bit is fixed to a drilled skull block, and accordingly the skull block is taken down.