The invention discloses a sealed anode microbiological fuel cell and submerged plant artificial wetland coupling system. The sealed anode microbiological fuel cell and submerged plant artificial wetland coupling system comprises an artificial wetland, an anode structure, a cathode and a lead wire, wherein the artificial wetland comprises a bottom mud region, a sewage region and a submerged plant;the sewage region is located above the bottom mud region; the submerged plant is planted in the sewage region; the anode structure comprises an anode and a shell body; a hollow chamber is remained inthe shell body; a through hole is formed in a side wall of the shell body; the anode is arranged in the hollow chamber; the anode structure is arranged at the bottom mud region; the cathode is arranged in the sewage region; the cathode and the anode are connected through the lead wire; microorganism films are attached on the surfaces of the cathode and the anode. The submerged plant is introduced,so that the content of dissolved oxygen adjacent the cathode is effectively increased; the cost is low, and an energy source is not consumed; the submerged plant also has the effect of removing pollutants at the same time, and the treatment effect of a whole device is improved.