The invention discloses a treatment method of wastewater generated by preparation of pyridoxal through pyridoxine and special equipment. An oxidant is adopted for oxidizing a soluble manganese salt insewage, insoluble manganese dioxide solid is prepared, and manganese dioxide solid is filtered and recycled; sewage obtained after recycling of manganese dioxide is then subjected to electrolysis soas to improve the B/C, and then subjected to activated carbon decoloration and biochemical treatment. Through the combination of oxidation, electrolysis, auxiliary decoloring and biochemical treatment, pyridoxal oxidation wastewater is subjected to combination treatment, not only manganese dioxide resources can be recycled, but also the problems that the cost is high and the biochemical treatmentis not applicable can be solved, and multiple purposes are achieved. The method is simple, efficient and low in cost.