The invention relates to twin drugs of N-benzyl substituted 4-aminosalicylic acid derivative and Tubastatin A and application of the twin drugs. The twin drugs are accordant with the structural general formula shown in the description, wherein R1 and R2 represent -Cl, -Br or -C(CH3)3, and R3 represents C1-C6 alkyl. The twin drug has good pesticide effect to cerebral infarction and can be used forpreparing drugs for treating cerebral apoplexy.