The invention relates to a comprehensive utilizing method of high-arsenic polymetallic gold ores and belongs to the technical field of the comprehensive recycling and utilizing of low-value noble metal ore resources. The method adopts a combined technology of a wet process and a pyrogenic process. In the process of the wet process, the efficient separation of antimony from other valuable metals isrealized through the electric potential control of an efficient leaching agent 1, raw antimony is obtained by carrying out electrodeposition on leachate, fine antimony is obtained after impurities are removed, a crystal sodium sulfide byproduct is obtained by treating waste electrolyte, arsenic oxide is obtained by separating leaching slags by the pyrogenic process, and metallic arsenic is obtained through further reduction. Waste liquid and slags, which are produced in the process, are recycled in a closed loop, so that secondary pollution cannot be caused to the environment.