The invention discloses a compression refrigeration system for permafrost degradation prevention. The system relates to the technical field of permafrost degradation prevention. The system comprises arefrigeration unit, a temperature signal acquisition unit, a central control unit and a power supply unit. The input end of the refrigeration unit is connected to the output end of the central control unit so as to regulate the temperature of the permafrost. The temperature signal acquisition unit is connected to the input end of the central control unit, which is used for collecting the temperature signal of the permafrost, and sending the temperature signal to the central control unit. The central control unit controls the on and off of the refrigeration unit based on the temperature signalof the permafrost. The output end of the power supply unit is connected to the other input end of the central control unit, which is used for supplying power to the central control unit and the refrigeration unit. The system is compact in structure, covers small area, is powered by solar and wind energy, is energy-saving and environmentally friendly. A stable and reliable intelligent real-time regulation for the permafrost temperature is achieved. The seasonal factor restriction of the permafrost degradation prevention is overcome.