The invention relates to a high-strength and vibration-isolation column of a large mechanical test. The high-strength and vibration-isolation column is composed of a chromium-molybdenum alloy column body, an upper connecting plate, a middle connecting plate, a lower connecting plate, a thin-layer rubber blanket, a thin steel plate, a lead core column, a rigid perforated piston, viscous fluid, a limiting sleeve, a viscous fluid damper outer cylinder, a rubber seal ring, a limiting spring, a screw, a fixing nut, a spacer and a limiting nut. Stable bearing and vibration isolation under the effectof high-strength vibration can be achieved. The chromium-molybdenum alloy column body has the characteristics of being high in strength, high in hardness, resistant to abrasion, high in stability, good in fatigue durability, high in tensile strength and the like, the vibration-isolation capability, the structural stability and the durability of the vibration-isolation column are greatly improvedthrough combination using of a lead-core thin steel plate rubber spacer and a viscous fluid damper, and the requirements of a precise mechanical test instrument for the high-strength bearing capability, the fatigue failure resistance and vibration isolation of bearing vibration-isolation supporting under the vibration effect are met. The high-strength and vibration-isolation column has very important scientific significance and practical value for developing geotechnical engineering large mechanical precise test instruments.