The invention provides a pressure sensor automatic adjustment device with an electric proportional valve. The pressure sensor automatic adjustment device comprises a high-low temperature test chamber,a pressure adjustment device and a control system, and the control system comprises an industrial personal computer, a voltage module and an electromagnetic valve drive mechanism. The electromagneticvalve drive mechanism controls opening and closing of electromagnetic valves of the pressure adjustment device separately, the voltage module is connected with the SMC electric proportional adjustment valve, and the industrial personal computer acquires a pressure value acquired by a second pressure gage, automatically adjusts the opening and closing state of the electromagnetic valves accordingto a set pressure value and adjusts the voltage value of the SMC electric proportional adjustment valve through the voltage module; linear variation of pressure in the high-low temperature test chamber is achieved, pressure variation is achieved through opening and closing of the corresponding electromagnetic valves and the SMC electric proportional adjustment valve, the pressure in the high-low temperature test chamber can be linearly adjusted, any pressure within an allowable pressure value range can be set, and thus detection of the detection precision of pressure sensors is improved.