The invention provides a touch display substrate and a touch display device. The touch display substrate comprises an underlayer substrate which comprises a display area and a lead area, multiple touch electrodes and multiple wires are arranged in the display area, the wires comprise touch electrode wires used for being connected with the touch electrodes and auxiliary wires which are not connected with the touch electrodes, at least two wires are arranged in an orthographic projection area of each touch electrode on the underlayer substrate, multiple leads are arranged in the lead area, and each wire is connected with a touch signal output end of a driving circuit through the corresponding lead. Accordingly, at least two wires are arranged in the orthographic projection area of each touchelectrode on the underlayer substrate, and then the at least two wires can be distributed in the area where the touch electrodes are located as uniform as possible, the problem that the touch electrode wire distribution is nonuniform is solved, and the display uniformity of the touch display device containing the touch display substrate is improved.