An auto-loop regulation system for a voltage regulator receives a plurality of pre-determined loop parameters through an interactive computing equipment, and the voltage regulator operates according to the plurality of pre-determined loop parameters, wherein the interactive computing equipment regulates at least one of the loop parameters automatically in real time according to an online loop value when the voltage regulator is operating online, and the interactive computing equipment keeps regulating the loop parameters until the online value of the voltage regulator matches with a target value.