The invention discloses an adjustable artware fastening device. The adjustable artware fastening device comprises a working groove, wherein two oppositely-arranged fixing plates are arranged in the working groove, each fixing plate comprises a vertically-arranged main plate and side plates vertically connected to the two ends of the main plate, the slide plates are slidably connected with the inner sidewall of the working groove, and a drive rod is connected to one side surface away from the side plates, of the main plate; and soft bags are arranged on the opposite wall surfaces of the two fixing plates, and the soft bags are internally filled with polyurethane particles. According to the fastening device disclosed by the invention, through the arrangement of the soft bags, the shapes of the soft bags can be deformed when the soft bags make contact with the surface of artware, the soft bags are internally filled with the polyurethane particles, so that the soft bags can be randomly deformed due to extrusion and completely bonded with the surface of artware, the surface of artware can be prevented from being worn, the artware is uniform in stress, and stress concentration at some parts in a fixing process is avoided; and flexible adjustment can be carried out according to the dimensions of the artware.