The invention discloses a novel noise reduction wheel axial flow ventilation fan which comprises fan blades (2). A motor (3) is connected to the center of the fan blades (2). A layer of shell (1) is arranged at the outer portion of the fan blades (2). The lower surface of the shell (1) is connected with a support (4). A base (5) is connected to the lower surface of the support (4). A pressing block (6) is arranged on the base (5). Wheels (7) are arranged on the lower surface of the base (5), and noise reduction blocks (8) are installed in the wheels (7). The novel noise reduction wheel axial flow ventilation fan has the beneficial effects that the iron pressing block is additionally arranged, the center of gravity of the fan is greatly improved, and the fan can work more stably and more effectively. Due to the arrangement of the wheels, the fan can be moved and carried more conveniently, in the pushing process of the wheels on the rubber surface, vibration and bumping caused by the uneven road surface can be relieved. Due to the design of the noise reduction blocks, noise produced during moving can be reduced, and the environment is protected.