The invention provides a multi-parameter real time monitoring early warning method for dangerousness of a closed region and belongs to the technical field of underground project monitoring. The methodincludes two parts comprising surrounding rock stability monitoring and pollutant state monitoring implemented according to an underground part and a ground part. According to the invention, an earlywarning threshold value is set through acquired initial data and routine surrounding rock stability evaluation is performed. Results are divided into levels indicating safe, unstable and dangerous. When the surrounding rock stability is in the dangerous level, closing measures are taken. When the surrounding rock stability is in the unstable level, pollutant leakage safety evaluation is performedand results are divided into levels indicating safe and unsafe. When the pollutant leakage safety evaluation result indicates unsafe, closing measures are taken. According the invention, data for judging safety of surrounding rock safety and data for judging pollutant stability can be acquired effectively. Judgment on dangerousness of pollutants in different monitoring segments can be made in real time through data evaluation and response to dangerous regions can be given timely.