The invention discloses a quinoline-indole derivative and application thereof in preparation of a drug used for treating, improving and/or preventing alzheimer disease. The quinoline-indole derivativedisclosed by the invention is a multi-target anti-alzheimer disease active molecule, has the effects of inducing increase of number of neure of nerve cells PC12, neuronal differentiation and antioxidation and inhibiting Abeta aggregation and depolymerization, can promote formation of cerebral hippocampal neuron of an adult mouse and can improve APP/PS1 cognitive capability and spatial memory of an alzheimer disease mouse.