The invention provides to a preparation method of high color fastness and lightfast bright red. The preparation method adopts superfine emulsion polymerization and conducts surface coating modification of lightfast red pigment particles with styrene and Methacryloxytrimethylammonium chloride copolymer. For one thing, polymer coats the surface of lightfast red, thus preventing the aggregation between pigment particles, improving the stability of printing ink, enabling uniform and fine pigment particles to be better wrapped by adhesive and the surface of the dried ink to be smooth, enabling thebright red to be washable, rub resistant and the like, and increasing color fastness. For another thing, due to the fact that methacryloxytrimethylammonium chloride is a cationic polymerization monomer, the surface of the prepared lightfast red pigment particles is provided with positive charge which can be better absorbed on the fabric surface with negative charge and strengthen the binding forcewith the fabric, thus further improving the color fastness of the printing ink.