The invention discloses a centralized protection method and system of software asset. The method can comprise the steps of virtualizing software and a corresponding operating system to obtain mirror images of the software and the system and saving the mirror images of the software and the system to a processing unit; making the processing unit search for the mirror images of the software and the system according to a user request and call a calculation unit to create a virtual machine; making a user log in to the calculation unit through a terminal and use the virtual machine to run the software. Through the virtualized technology, centralized protection and multi-time utilization of the software asset are achieved.