The invention discloses a neurosurgical ultrasonic focusing assisted three-stage atomization cooling and postoperative wound film forming device. The device solves the problems that a skull base tumorremoval device in the prior art cannot cool a grinding zone and timely cover a wound. The device has the advantage of realizing timely coating. According to the technical scheme, the neurosurgical ultrasonic focusing assisted three-stage atomization cooling and postoperative wound film forming device is provided with a transducer housing, an amplitude changing rod II is arranged in the transducerhousing, at least two layers of piezoelectric ceramic sheets II are arranged on the top of the amplitude changing rod II, and electrode sheets connected with an ultrasonic generator are arranged between two adjacent piezoelectric ceramic sheets II. The bottom of the transducer housing is of a semi-spherical structure. A plurality of piezoelectric elements connected with the ultrasonic generator are arranged on the inner side of the spherical structure. A nozzle is arranged at the bottom of the amplitude changing rod II and is connected with a medical nano fluid storage cup, compressed gas canalso be introduced into the nozzle, and an electrode is also arranged on the inner side of the nozzle.