The invention discloses an ultrasonic-assisted high pressure eliminating device for glue scales of a packaging machine. The device comprises a multifunctional ultrasonic vibrating glue eliminating mechanism and a high pressure water glue cleaning mechanism. The multifunctional ultrasonic vibrating glue eliminating mechanism comprises an ultrasonic vibrator for generating sound wave vibration, theultrasonic vibrator is composed of an ultrasonic transducer and an ultrasonic amplitude-change pole, and a working head for eliminating glue is fixedly mounted on the end portion of the ultrasonic amplitude-change pole detachably; the high pressure water glue cleaning mechanism comprises a high pressure nozzle mounted on the ultrasonic vibrator through a support, the high pressure nozzle moves forward to not exceed the working head of the multifunctional ultrasonic vibrating glue eliminating mechanism, and the effluent direction of the high pressure nozzle points to the working head obliquely;and a water feeding part of the high pressure nozzle is connected to a high pressure water source. The ultrasonic-assisted high pressure eliminating device disclosed by the invention eliminates coagulated glue scales through high frequency vibration and high pressure water jets of the working head, so that the coagulated glue scales are eliminated quickly and thoroughly.