The invention belongs to the technical field of metal additive manufacturing, and particularly relates to a double-metal electron beam wire-melting additive manufacturing method. According to the double-metal electron beam wire-melting additive manufacturing method, an electron gun, a metal A wire feeder and a metal B wire feeder are adopted to cooperatively conduct printing on a base plate in a vacuum chamber; the double-metal electron beam wire-melting additive manufacturing method comprises the steps that a workpiece model with an inner layer being metal A and an outer layer being metal B is generated by utilizing a computer; the layer thickness size of a metal A printing piece and a metal B printing piece and the width size of a deposited layer are planned by utilizing layered processing software, and route planning is conducted according to the order that the inner layer is printed first and then the outer layer is printed; and a document after being subjected to splicing and route planning is imported into a main control unit. The double-metal electron beam wire-melting additive manufacturing method overcomes the disadvantages that a traditional double-metal compound interface adopts a mechanical bonding type which is small in compound binding force, easy to layer and is not suitable for brittle metal materials and a metallurgical bonding type which is high in productioncost and is suitable for mass production; and the double-metal electron beam wire-melting additive manufacturing method can be suitable for metal forming of two different materials, the efficiency ishigh, the metallurgical quality is good, and the double-metal electron beam wire-melting additive manufacturing method has high market application and promotion prospects.