The invention discloses a fruit packaging box with an anti-collision function capable of realizing rapid loading and unloading. The fruit packaging box with the anti-collision function capable of realizing rapid loading and unloading comprises a packaging box body and a packaging box cap. The packaging box cap is arranged at an opening at the upward side of the packaging box body. The packaging box is characterized in that a side sliding plate is arranged right ahead of the packaging box body in a sliding manner; plugholes arranged in rows are formed in the inner wall, which is located opposite to the side sliding plate, of the packaging box body; each row of the plugholes are sequentially arranged from down to up; fixing holes arranged in a single row are formed in the inner walls at theadjacent sides, which are close to the side sliding plate, of the packaging box body; layer plates used for loading fruits are inserted on the plugholes; long separating plates and short separating plates are arranged at the outer walls of the layer plates; each long separating plate and the corresponding short separating plate together form a single fruit storage compartment; slideable fixing plugs are arranged right ahead of the layer plates; and the fixing plugs can be inserted into the fixing holes at two sides of the inner walls of the packaging box body. The fruit packaging box with theanti-collision function capable of realizing rapid loading and unloading provided by the invention is capable of overcoming the disadvantages of the prior art.