A multi-target perception intelligent sensor of the present invention comprises a packaging substrate, external ports are arranged at one end of the packaging substrate, and an insertion layer is arranged on the upper side surface of the packaging substrate. The insertion layer is equipped with the horizontal through holes uniformly, TSV penetrate the insertion layer, and the upper ends of the TSVare equipped with the micro bumps. A first CMOS signal processing circuit, a second CMOS signal processing circuit, an RF chip, a physical sensor, a processor and a 3D memory chip are arranged at theupper side of the insertion layer, a chemical sensor is arranged at the upper side of the second CMOS signal processing circuit, and the second CMOS signal processing circuit is connected with the chemical sensor electrically. The first CMOS signal processing circuit is connected with the physical sensor electrically, the first and second CMOS signal processing circuits are both connected with the processor, and the processor is also connected with the RF chip and the 3D memory chip separately. The multi-target perception intelligent sensor of the present invention has the advantages of beinghigh in integration degree, strong in cooperativity, low in cost and small in size, and being stable and reliable.