The invention provides a thin film packaging structure, a display device and a packaging method of the display device. The thin film packaging structure has a middle part corresponding to a display region of a to-be-packaged substrate, and an edge part corresponding to a peripheral region of the to-be-packaged substrate; the thin film packaging structure comprises a first inorganic thin film usedfor covering the to-be-packaged substrate, an organic thin film formed on the first inorganic thin film, and a second inorganic thin film for covering the organic thin film, wherein the thin film packaging structure also comprises a blocking structure used for blocking a fluid organic material in formation of the organic thin film; and the blocking structure is positioned on the edge part and surrounds the middle part. By virtue of the thin film packaging structure, complete flowing and diffusing of the organic material in the thin film packaging structure can be ensured, complete planarization in an AA region can be realized, the organic material can be only limited in a certain region outside the AA region for flowing and diffusing, and a narrow framer is realized.