The invention belongs to the field of veterinary drugs and relates to a taste-masking intestinal immediate release type tilmicosin micro-nano dry suspension and a preparation method thereof. The taste-masking intestinal immediate release type tilmicosin micro-nano dry suspension is prepared from, by weight, 5-30 parts of tilmicosin, 10-35 parts of weak-acid ion exchange resin, 5-30 parts of methylacrylic acid copolymer, 2-15 parts of a suspending agent, 0.2-5 parts of a solubilizer, 2-15 parts of a disintegrating agent, 0.1-1 part of an acidity adjusting agent and 0.5-2 parts of corrigent. Thetaste-masking intestinal immediate release type tilmicosin micro-nano dry suspension which is convenient to apply, can be dispersed and suspended in water for drinking and can also be used for mixinghas advantages of high palatability, stability, quick action, high efficiency, convenience in application and the like.