The invention relates to a door open-close device for a manned operation submersible. The device comprises a side door, first side door connection rods are mounted at two ends of the inner side of theside door respectively, and first linkage rods are hinged to the lower portions of the first side door connection rods; second linkage rods are hinged to the head portions of the first linkage rods,and third linkage rods are hinged to the head portions of the second linkage rods; a top door is arranged on the top of the side door, first top door connection rods and second top door connection rods are mounted at two ends of the bottom surface of the top door, and the third linkage rods are connected to the middles of the first top door connection rods through hinges. The device further comprises a driving hydraulic cylinder, and one first side door connection rod is fixed to the output end of the driving hydraulic cylinder; second side door connection rods are further mounted at two endsof the inner side of the side door. The door open-close device solves the problem of excessively large protruding line shape after an irregular open-close door is opened, and is more beneficial to thenavigation safety of the submersible after being started.