The invention discloses a change constraint planning-based regional high-voltage distribution network wheeling method. The method comprises the following steps of: providing a high-voltage distribution network change constraint wheeling model by taking a 110kV transformation unit group feasible topological state as a control object on the basis of a topology reconfiguration ability of a high-voltage distribution network; carrying out multi-state modeling on a random variable by utilizing a probability density function of a wind power-load error; and constructing a high-voltage grid operation optimization technology by taking topology reconfiguration has a way under an uncertainty condition. The method is capable of effectively dredging absorptive contradiction of high-voltage grids after non-uniform access of high-permeability wind power and beneficial for enhancing flexible utilization rate of high-voltage grid assets so as to restrain blocking risks.