The invention discloses a fusing, spraying and pelleting device for ceramic balls of proliferation agents and a method of the fusing, spraying and pelleting device. The fusing, spraying and pelletingdevice comprises a hearth, a pressurization device, a pressure tube, a blowing cavity, a drip tube, a collector and a reverse blowing tube. According to the method, proliferation agent powder is addedinto the hearth from the pressure tube and heated into a molten state through electromagnetic induction heating, proliferation agent liquid drops from the drip tube through pressurization to form proliferation agent liquid drops, the proliferation agent liquid drops are blown into uniform small drops through blowing air, the small drops are dispersed outwardly in a tapered state, inertia gases blown from the reverse blowing tube carry the proliferation agent liquid drops to reduce falling speed of the proliferation agent liquid drops, and the proliferation agent liquid drops are fully cooledto form the ceramic balls of the proliferation agents. By the fusing, spraying and pelleting device and the method thereof, tritium proliferation agent materials of fusion reactors can be produced massively to provide tritium sources for the fusion reactors.