The invention discloses an efficient anti-staining detergent for garment washing and a preparation method of the efficient anti-staining detergent. The efficient anti-staining detergent is prepared from components in percentage by mass as follows: 5%-15% of polyvinylpyrrolidone, 10%-40% of a maleic acid-acrylic anhydride copolymer, 10%-20% of fatty alcohol polyoxyethylene ether, 5%-15% of secondary alkyl sodium sulfonate, 5%-8% of linear alkyl benzene sulfonic acid, 0.05%-0.1% of a preservative and 1.9%-64.95% of deionized water. Polyvinylpyrrolidone, the maleic acid-acrylic anhydride copolymer and fatty alcohol polyoxyethylene ether (peregal O) are taken as the raw materials, all the components play own role and have a synergistic effect, so that the detergent has a good anti-staining effect, phenomena such as mutual staining, color mixing and the like between different fiber materials and clothes in different colors are prevented in the garment washing process, and quality and valueof the product are improved; the raw materials are all environmentally friendly, non-toxic, harmless, non-irritant and pollution-free.