The invention provides a method for producing lubricant base oil with hydrofining. The method comprises the following steps of mixing raw oil and hydrogen, and enabling a mixture to sequentially passthrough an upper bed layer and a lower bed layer in a hydrofinishing reactor, wherein an inlet hydrogen partial pressure of the hydrofinishing reactor is 10-20MPa, the upper bed layer and the lower bed layer are both filled with a catalyst with the feeding amount being 25-30t/h, a ceramic ball with the outside diameter being 2.5-5.0mm is arranged at the upper end of the upper bed layer, a ceramicball with the outside diameter being 5.0-7.0mm is arranged at the lower end of the upper bed layer, a reaction temperature of the upper bed layer is 210-230 DEG C, a ceramic ball with the outside diameter being 12.0-13.0mm is arranged at the lower end of the lower bed layer, and a reaction temperature of the lower bed layer is 280-300 DEG C. The method has the advantages of hydrodenitrogenation, capabilities of obviously increasing and improving the aromatic hydrocarbon saturation degree, the viscosity index, the chroma and the oxidation stability of a product and obtaining white oil and the lubricant base oil with high quality, and on the other hand, greatly lowering the energy consumption of the device and reducing the consumption of natural gas, water vapor and electric quantity.