The invention relates to the field of dispatching automation systems, in particular to an automated master station operation and maintenance operation order system for power grid dispatching, and an overall-process anti-mistake method. The system comprises an object layer, an interface layer and an application layer, wherein the object layer mainly aims at object which needs to be operated; the interface layer is mainly used for providing a data access way for each operation object; and the application layer is mainly used for carrying out a specific operation on the specific operation object.By use of the scheme of the invention, functions, including automated execution, mass execution, anti-mistake checkout, result examination, historical records and the like, for the dispatching automation system operation order are integrally realized, and the operation and maintenance efficiency of the system is improved.