The invention belongs to the field of power grid safety and provides an electrical control system of a safe mouse catching device for power grid. The electrical control system comprises a box body made of an insulating material; the box body is provided with a box door; an electric shock component and a bait are arranged in the box body; an open door maintaining component, a bait detection module,a closed door maintaining component, a closed door detection module and a power module are also arranged in the box body, wherein the open door maintaining component is used for maintaining an open state of the box door; the bait detection module detects whether a mouse eats the bait while controlling the open door maintaining component; the closed door maintaining component maintains a closed state of the box door; the closed door detection module controls the closed door maintaining component while controlling the electric shock component; the power module supplies power to the electric shock component as well as the open door maintaining component, the bait detection module, the closed door maintaining component and the closed door detection module. The system provided by the inventionis very safe to use; high tension electricity for mouse electrocution is switched on in an insulating closed space; with perfect safety measures, the system avoids harm to human body. The system provided by the invention has the advantages of simple structure, rare failure and convenience and durability.