The invention relates to a regeneration method for an isodewaxing catalyst. The isodewaxing catalyst is a precious metal/molecular sieve catalyst. The regeneration method is characterized by comprising the following steps: placing a deactivated catalyst into a reactor; and successively subjecting the deactivated catalyst to washing with cleaning oil, purging with inert gas, hydroconversion and hydrogenolysis, oxygen oxidation and hydrogen reduction so as to restore the activity of the catalyst. Different from conventional out-of-reactor regeneration methods, the method provided by the invention removes toxic matters and impurities on the surface and in the pore channels of the catalyst in the reactor through physical processes like on-line solvent cleaning and purging with inert gas such as nitrogen and chemical processeslike hydroconversion, hydrogenolysis and low-temperature oxidation without dismounting of the catalyst, so the method avoids dismounting and filling of catalyst duringout-of-reactor regeneration, degradation of noble metals due to high-temperature oxidation during out-of-reactor regeneration and deposition of sulfate converted from sulfur species on the surface ofthe catalyst during high-temperature oxidation of the sulfur species, and can effectively extend the service life of the catalyst.