The invention discloses a prefabricated lightweight hollow core mold multi-ribbed sandwich panel which is composed of a transverse end plate, longitudinal rib beams and a lightweight concrete hollow strip plate. The lightweight concrete hollow strip plate is clamped between the transverse end plate and two adjacent longitudinal rib beams. The longitudinal rib beams are divided into edge rib beamsand middle rib beams. The cross section of each edge rib beam is in an inverse L shape, and the cross section of each middle rib beam is in an I shape. Top flanges of every two adjacent longitudinal rib beams are longitudinally broken and form a horizontal groove together with the top surface of the lightweight concrete hollow strip plate, and communicated transverse steel bars are disposed in thegroove. During construction, first a plurality of prefabricated lightweight hollow core mold multi-ribbed sandwich panels are installed, and then an assembly integrated type composite floor slab is formed through a post-cast overlapped layer. Due to the adoption of a unidirectional multi-ribbed sandwich structure, the bearing capacity is strong, the span of application is large, the lightweight concrete hollow strip plate is longitudinally disposed in the panel, a formwork for the multi-ribbed floor slab is saved, and the integration of structure and building energy saving is achieved. Therefore, the prefabricated lightweight hollow core mold multi-ribbed sandwich panel has the advantages of being light in self weight, good in heat insulation effect and low in cost. The market prospect iswide.