The invention provides a safe mousing device used for a power grid, comprising a box made from an insulating material, wherein an upward opening type lateral door is arranged on a pair of opposite side walls of the box, a conducting rod is arranged between the other pair of opposite side walls of the box, a conducting board is arranged at the bottom in the box, a lifting rod is arranged at the topsurface in the box, and a bait is hung at the tail end of the lifting rod. The lateral door is provided with a first detection component used for detecting and keeping the opening state of the lateral door, and is also provided with a second detection component used for detecting and keeping the closing state of the lateral door, and a bait detection component is arranged on the lifting rod. Thebox is also provided with an electric control module. The conducting rod, the conducting board, the first detection component, the second detection component and the bait detection component are all connected with the electric control module, and the electric control module is externally connected with a household power source. Detection components used according to the invention are all controlled by weak current, high voltage for killing mouse by electrocution is started in an insulated closed space, and therefore, safety measures are excellent, and not harm is caused to a human body. The safe mousing device is simple in structure, uneasy to fail and convenient and durable.