The invention discloses a resin flexible shaft heat sealing machine. One ends of resin flexible shafts for heat sealing are positioned by feeding devices on two sides, and are relatively clamped through workpiece clamping mechanisms; the resin flexible shafts are shifted between an upper mold and a lower mold according to preset position and pressure; a lower mold electromagnetic induction heatingdevice and an upper mold electromagnetic induction heating device respectively heat the upper mold and the lower mold according to preset position, temperature and time, so that the resin flexible shafts on two sides are in heat sealing and mutual melting; the resin flexible shafts are heated in two ways, so that the heat transfer efficiency is higher, the mutual bonding effect is more excellent,the finished product strength is higher, and the quality is more excellent; in order to guarantee the quality of the welding position and the cooling speed, multiple mediums are adopted in the upperand lower molds for cooling, so that the cooling is fast, and the size stability is high; warm water is recycled, and is automatically drained through a sewage pump to achieve energy conservation andenvironmental protection; and the device is higher in overall resource utilization rate, low in production cost and convenient for actual production and operation.