The invention discloses a cooperation structure of a lampholder and a lamp bulb. The cooperation structure comprises a cover enclosure with the interior being provided with a cavity and the bottom endbeing open, the lamp bulb is installed on the cover enclosure, the upper end of the lamp bulb is inserted into the cavity, a pair of binding posts is fixed to the top of the cover enclosure, the binding posts extend into the cover enclosure after penetrating through the cover enclosure, and a circuit board is arranged in the position, above the lamp bulb, of the cover enclosure; a pair of conductive contacts is fixed to the upper end face of the circuit board, a pair of elastic conductive needles used for abutting against contact points at the upper end of the lamp bulb to achieve electric connection is fixed to the lower end face of the circuit board, and a driving mechanism used for driving the circuit board to move downwards to enable the conductive contacts to break away from the binding posts in the lamp bulb dismantling process is installed on the cover enclosure; and bosses are arranged on the outer walls of the two sides of the lamp bulb, a sliding groove capable of allowing the bosses to slide in is formed in the inner side wall of the cover enclosure, and a limiting structure is arranged between the lamp bulb and the cover enclosure. According to the cooperation structure, occurrence of electric shock accidents can be effectively avoided in the lamp bulb replacing process, and convenience can be provided for lamp bulb replacing.