The invention provides a screen color adjustment method and device and a mobile terminal. The method comprises the steps that whether a background color of a fixed content display region is matched with a background color of a variable content display region in a display interface of a screen is detected; if not, a background color of a preset region in the variable content display region is acquired; color picking processing is performed on the background color of the preset region to obtain a target color; and the background color of the fixed content display region is replaced with the target color. Through the screen color adjustment method and device and the mobile terminal, the background colors of the display interface of the whole screen can be coordinated and unified, the interface display effect of the screen is improved, full-screen immersive experience of a large-screen mobile terminal is brought, and user visual experience is improved.