The invention provides a wire fixing frame for a computer mainframe. The left side of a wire winding reel is provided with a horizontal groove which is formed in a way that a horizontal plate penetrates through to the center of the left side of the wire winding reel; a left wire winding reel support is provided with a support groove which is formed in a way that the horizontal plate penetrates through the left wire winding reel support; the support groove can communicate with the horizontal groove; a second turn plate rotates only when the upper end of a first control pin is positioned insidea first arc-shaped groove, and a control rod is inclined towards a first turn plate at the moment; the first turn plate rotates only when the upper end of a second control pin is positioned inside a second arc-shaped groove; one end, close to a fixed clamping block, of a turn plate shaft is fixedly provided with a cam which is connected with a connecting component; the cam can be used for drivinga movable clamping block to move up and down through the connecting component; and the lowest position of the cam is farthest away from a mounting plate when the second control pin is positioned inside the second arc-shaped groove. The wire fixing frame provided by the invention can be used for fixing and dismounting computer wires quite conveniently and quickly and can be used repeatedly, and redundant data cables can be collected by the wire winding reel so as to prevent potential safety hazards caused by over length of the wires.