The invention relates to a salt crystallization separation device and process capable of realizing zero emission and discloses a zero-emission treatment method and device for high-salt wastewater. Wastewater is subjected to intensified softening treatment with a tubular microfiltration membrane and then enters a special separation membrane for separation of monovalent ions and divalent ions. Further concentration is performed with a high-pressure reverse osmosis or selective permeable electric ionic membrane according to the properties of materials on a fresh water side and a concentrated water side, and the evaporation system treatment scale and scaling tendency are reduced to the maximum extent. Crystalline salt is obtained by use of a low-temperature normal-pressure crystallizer at an evaporative crystallization section, wastewater and crystalline salt are finally recycled, the investment is saved, the wastewater operation cost is significantly reduced, and zero emission of wastewater can be really realized.