The invention belongs to the technical field of fine chemicals. The invention aims at providing a production process of a high-quality fatty alcohol polyoxyethylene ether sulfate with high content ofactive matters, light color and low dioxane residues; and simultaneously, the process flow is simple and can be conveniently realized on an existing production device of the fatty alcohol polyoxyethylene ether sulfate without changing sulfonation equipment. The technical scheme is as follows: the production process of the high-quality fatty alcohol polyoxyethylene ether sulfate comprises the following steps: 1) pre-dissolving an appropriate amount of sulfonation stabilizer in fatty alcohol polyoxyethylene ether; 2) sulfonating the fatty alcohol polyoxyethylene ether pre-dissolved with the sulfonation stabilizer on an existing vapor phase SO3 film type sulfonation device according to an existing sulfonation production process of the fatty alcohol polyoxyethylene ether sulfate; and 3) enabling an sulfonated acid ester to directly enter a neutralization system without aging and producing the fatty alcohol polyoxyethylene ether sulfate according to an existing neutralization process.