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CN107936285A 磁性四氧化三铁-聚乳酸复合多孔微球的制备方法及用途 无效 - 驳回

磁性四氧化三铁-聚乳酸复合多孔微球的制备方法及用途
摘要：
本发明提供了一种磁性四氧化三铁-聚乳酸复合多孔微球的制备方法，其包括如下步骤：S1：将聚乳酸溶解后，加入磁性纳米四氧化三铁，形成混合溶液；S2：向所述混合溶液中加入预热后的甘油，搅拌形成乳液；S3：将所述乳液在-50～-20℃下进行淬火后，加入冰水混合物，并控制每8h更换一次冰水混合物，共更换2天后，进行冷冻干燥，得到所述磁性四氧化三铁-聚乳酸复合多孔微球。本发明的优点在于：本发明制备的磁性纳米四氧化三铁-聚乳酸复合多孔微球由直径为80～150nm的纳米纤维组成，大小均匀，直径为40～70μm，并且具有孔隙率高、比表面积大等特点；本发明所采用乳液法和热致相分离法结合，工艺简单，适合于大量制备。
摘要（英）：

The invention provides a preparation method of magnetic ferroferric oxide-polylactic acid composite porous microspheres. The preparation method comprises the following steps: S1, after dissolving polylactic acid, adding magnetic nanometer ferroferric oxide to form a mixed solution; S2, adding preheated glycerinum into the mixed solution and stirring to form emulsion; S3, quenching the emulsion at-50 to -20 DEG C, adding an ice-water mixture, controlling to change the ice-water mixture for once every 8 hours, and freeze-drying after changing for 2 days to obtain the magnetic ferroferric oxide-polylactic acid composite porous microspheres. The preparation method has the following advantages: the magnetic ferroferric oxide-polylactic acid composite porous microspheres prepared with the method comprise nanofiber with the diameter of 80 to 150 nm, are uniform in size and 40 to 70 um in diameter, and have the characteristics of high porosity, large specific surface area and the like; and anemulsion method and a thermally induced phase separation method are combined, and the process is simple and suitable for large-scale preparation.

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