The invention provides layered mining methods for a multilayer ore body of an in-situ leachable sandstone type uranium ore deposit. According to one of the layered mining methods, the multilayer ore body is mined in a mode of shared liquid injection and separate liquid pumping, namely, a single drilled hole is adopted as a liquid injection hole, layered liquid injection is conducted through the liquid injection hole, and thus sharing of the liquid injection hole by the multilayer ore body is achieved; and a plurality of drilled holes are adopted as liquid pumping holes, each liquid pumping hole corresponds to a single-layer ore main body for separate liquid pumping, and thus liquid pumping of the multilayer ore body is conducted through the liquid pumping holes separately. According to theother layered mining method, the multilayer ore body is mined in a mode of shared liquid injection and shared liquid pumping, namely, a single drilled hole is adopted as a liquid injection hole, layered liquid injection is conducted through the liquid injection hole, and thus sharing of the liquid injection hole by the multilayer ore body is achieved; and a single drilled hole is adopted as a liquid pumping hole, layered liquid pumping is conducted through the liquid pumping hole, and thus sharing of the liquid pumping hole by the multilayer ore body is achieved. The layered and separate mining method for the multilayer ore body is developed and put into practice and is an effective measure for saving the drilling cost, increasing the resource utilization rate and avoiding resource waste.