The invention relates to a square-crossing rectangular drift type panel underhand cemented filling mining process adopted for the exploitation of a lead-zinc ore body, and belongs to the technical field of mining. According to the square-crossing rectangular drift type underhand cemented filling mining process, an ore body is divided into a middle level, sublevels, stratums and panels; one middlelevel is in charge of 2 to 6 sublevels; one sublevel is in charge of 2 to 4 stratums; one sublevel is also divided into multiple panels along a trend of the ore body; in a stoping process, one panel is used as a stoping unit; the stoping is carried out according to a spaced rectangular drift stoping sequence that a lower stratum follows after an upper stratum in the panels and an exterior one follows after an interior one, an easy one follows after a difficult one and two end ones follow after a middle one in planes of the stratums; further, stoping rectangular drifts of adjacent upper and lower stratums in the panels are arranged by adopting square crossing; the mining process is easily managed and easily operated and popularized and is safe and efficient in exploration, and has a high resource stoping rate and a low dilution rate.