The invention discloses a main network and distribution network integrated regulation and control system. The system comprises a commercial database, a main network model real-time library, a main network application cluster, a distribution network model real-time library, a distribution network application cluster, a basic processing result real-time library and a distribution network regulationand control integrated analysis application module; electric model data is from an external model data center, and graph-module data interaction is carried out through an interface server; by adoptionof the main network application cluster and the distribution network application cluster, independent basic data processing is carried out; and the distribution network regulation and control integrated analysis application module unifies a display form so as to realize distribution network regulation and control integration. The system does not adopt a main/distribution mode, but adopts an application cluster manner, so that the application analysis processing ability and fault tolerant ability are improved, and the system operation efficiency and stability are greatly improved.