The invention discloses a polyimide composite insulation seamless wrapping wire. A plurality of nickel-plated copper wires are twisted in a concentric manner to form a conductor, the external part ofthe conductor is wrapped by a polytetrafluoroethylene-polyimide composite tape to form an inner insulating layer, the external part of the inner insulating layer is wrapped by a polytetrafluoroethylene sealing tape to form an outer insulating layer, and finally high-temperature sintering is performed. According to the polyimide composite insulation seamless wrapping wire with an optimized design,the surface of a polyimide film is coated with polytetrafluoroethylene so that the dry and wet arc resistance of the cable can be effectively improved, and the external part of the polyimide inner insulating layer is wrapped by the polytetrafluoroethylene sealing tape so that the sealing performance is enhanced; besides, optimized selection of processing process parameters is performed so that thecombination reliability between the inner insulating layer and the outer insulating layer is greatly improved, and the tightness of the insulating layers of a product can be improved.