The invention discloses a travelling pesticide sprayer, comprising: a cart body that includes a frame and a travelling power mechanism; a shifting device that includes a shifting rack, a shifting power mechanism and a hydraulic cylinder; a pesticide barrel; a liquid pesticide discharge device; a plurality of liquid pesticide discharge pipes; a control device that controls the travelling power mechanism, the liquid pesticide discharge device, the shifting power mechanism and the hydraulic cylinder to operate; a pair of travel switches. The travelling power mechanism drives the cart body to travel by a standard travel distance value along one direction; the liquid pesticide discharge device draws water or liquid pesticide in the pesticide barrel and discharges into the liquid pesticide discharge pipes; a power output rod of the hydraulic cylinder is extended down and supports the cart body off a ground; the shifting power mechanism drives the cart body to move from a first portion to a second portion; the power output rod of the hydraulic cylinder retracts up so that the cart body contacts the ground; the travel switches are arranged at two ends of the shifting rack respectively. Thetravelling pesticide sprayer has the advantages that manpower is greatly saved, and crop irrigating or pesticide spraying efficiency is improved.